Notably, the AUC values for both SUMO3 and SEH1L exceeded 0.7 in both datasets, indicating strong diagnostic performance and supporting their potential utility as biomarkers for PD.SUMO3 and SEH1L were expected to serve as auxiliary indicators for the early diagnosis of PD and contribute to enhancing the accuracy and timeliness of PD diagnosis. This evidence concerns the gene SEH1L and Parkinson disease.