The results of the present study indicated that both secondary outcomes, FSH (P = 0.048) and hirsutism based on Ferriman-Gallwey (P = 0.042), were significantly improved in patients supplemented with crocin compared to placebo over the study period while the primary outcome, LH (P = 0.201) was insignificant. Here, PLOD1 is linked to Hirsutism.