Similarly, the GC-specific Senescence Score identifies patients with upregulated senescence markers and immunosuppressive features such as PVR-CD96 signaling and IL6/CXCL12-secreting CAFs, while drug repositioning reveals exisulind as a potent senolytic agent that synergizes with palbociclib to eliminate senescent GC cells [112]. Here, CXCL12 is linked to gastric cancer.