Additionally, molecular regulators such as CNOT3 and PAD2 modulate senescence: CNOT3 knockdown elevates p21 and SASP factors, while PAD2 inhibition suppresses Nrf2/HO1/AKT signaling, impairing tumor growth and amplifying IL6/p53-dependent senescence [266]. The gene discussed is TP53; the disease is neoplasm.