It has been recently shown that G4s in CRC-dysregulated lncRNAs GSEC, REG1CP, and LUCAT1 might be involved in CRC pathogenesis [47–49]; however, their role in the regulation of other lncRNAs known to be dysregulated in CRC such as LINC01589 (CTA-941F9.9), MELTF-AS1 (MFI2-AS1), and UXT-AS1 [50–52], with implications in cell proliferation, migration, and apoptosis, remain to be understood and pharmacologically exploited, which is precisely the aim of our current investigations. The gene discussed is MELTF-AS1; the disease is colorectal carcinoma.