Simultaneously, LncROR acts as a competing endogenous RNA for miR-145, derepressing Nanog and OCT4 expression to expand the CD133+ cancer stem cell pool and inhibit gemcitabine-induced apoptosis and G1/S arrest, resulting in a 30–50% increase in gemcitabine IC50 values in functional assays [97, 98]. Here, PROM1 is linked to cancer.