The GO analysis showed that DMPs identified between patients and controls were mostly enriched in four molecular functions (Figure S1, A), the most important of which were regulation and activation of GTPase, molecular functions that, in the molecular analysis, were associated with genes from the TBC1D family, including the gene TBC1D22A, whose DMP (cg08161306) was previously proposed as a potential biomarker of RA (see above). This evidence concerns the gene TBC1D22A and rheumatoid arthritis.