CD4 and infection: The modulation of immune receptors on mast cells and dendritic cells effectively facilitated neutrophil recruitment in septic mice [58]; modulation of CD4 + T cell migration and cytokine secretion significantly intervened acute liver injury in mice [59]; exhaustion of CD8 + T cells reduced acute liver injury in mice [56]; and sepsis was primarily characterized by an altered CD8 + T cell composition, which directly influences the CD8 + T cell response to the initial infection [60].