The findings regarding immune cell infiltration indicated that in sepsis, there was an elevation in mast cells activated infiltration, while infiltration of naive CD4 + T cells and resting mast cells diminished; in ALF, there was an elevation in plasma cells, CD8 + T cells, activated CD4 + memory T cells, and gamma delta infiltration T cells; conversely, infiltration of resting CD4 + memory T cells, follicular helper T cells, activated dendritic cells, activated mast cells and neutrophils diminished. The gene discussed is CD8A; the disease is Sepsis.