ITCH and Sepsis: The ROC curves of these 10 model genes that were consistently upregulated or downregulated in sepsis and ALF were created, revealing that the AUC values of the two critical genes, GABARAP and ITCH, were ≥ 0.7 in both conditions (Fig. 5F-G).The results indicated that GABARAP and ITCH might have played significant roles in influencing the onset and progression of sepsis combined with ALF.