NLRP3 and Sepsis: Research shows that pyroptosis plays a key role in the progression of sepsis [14]; exosome miR-30d-5p facilitates macrophage polarization and initiates pyroptosis, consequently advancing the onset of sepsis and its associated complications [15]; elevated levels of pyroptosis have been observed in ALF mice [16]; and the activation of cellular pyroptosis driven by the NLRP3 inflammasome worsens acute hepatic injury linked to sepsis during the inflammatory response [17].