Nociceptive nerve fibers, sympathetic nerve fibers, blood vessels, and osteoclasts were present in the FD lesions, and the dorsal root ganglia from male FD mice showed increased staining of activating transcription factor-3 and tyrosine hydroxylase, which are commonly associated with nerve damage in mouse models of chronic pain [93, 94]. The gene discussed is TH; the disease is Fabry disease.