While Gαs signaling activation in FD inhibited osteoblast maturation by activating Wnt/β-catenin signaling and inhibiting Hh signaling, loss of Gαs signaling is found to cause ectopic activation of Hh signaling and YAP transcriptional co-activator, which is an underlying mechanism of progressive osseous heteroplasia (POH, a genetic form of heterotopic ossification caused by loss of function variants in GNAS) [76, 77]. The gene discussed is GNAS; the disease is Fabry disease.