TLE cytokine/chemokine profiles were similar to LGI1 AE; AD patients had lower serum IL‐6 and CSF IL‐8/CXCL8 (p = 0.04; p = 0.01), and higher serum IL‐17A and GM‐CSF (p = 0.004; p = 0.01) than LGI1‐AE. Here, CXCL8 is linked to Alzheimer disease.