Among the genes with augmented induction in DOT1L-ko cells were members of protein complexes with known tumor suppressor functions (AP1, p53, forkhead transcription factors) as well as apoptosis mediators (CASP1, CASP4, CASP5, CASP10, TLR2, TLR3) (Fig. 4A). The gene discussed is CASP4; the disease is neoplasm.