Interestingly, in KMT2A::MLLT3 rearranged MOLM13 cells the same analysis revealed predominant binding of DOT1L to promoter regions and no relevant association with putative enhancers indicating a function in MPN cells that is distinct from KMT2A-rearranged leukemia (Supplementary Fig. 3C,D). This evidence concerns the gene KMT2A and leukemia.