Interestingly, also the incomplete genetic inactivation of DOT1L (sgDOT1L-clone1, Fig. 2B) had a significant impact on the fitness of cells treated with LSD1 inhibitors indicating a strong dependency of MPN-BP cells on high DOT1L expression levels (Supplementary Fig. 2C-F). Here, DOT1L is linked to myeloproliferative neoplasm.