Next, we employed our methylcellulose-based culture system (Supplementary Fig. 1B) to evaluate cell growth of two different primary MPN-BP patient samples and normal CD34+ cells from G-CSF mobilized peripheral blood mononuclear cells after RNAi-mediated knockdown of DOT1L and LSD1 inhibitor treatment. This evidence concerns the gene DOT1L and myeloproliferative disorder.