Next, we employed our methylcellulose-based culture system (Supplementary Fig. 1B) to evaluate cell growth of two different primary MPN-BP patient samples and normal CD34+ cells from G-CSF mobilized peripheral blood mononuclear cells after RNAi-mediated knockdown of DOT1L and LSD1 inhibitor treatment. Here, KDM1A is linked to myeloproliferative disorder.