Of note, among these genes were critical regulators of cell cycle progression (MYC, MYB, MYCBP1, CHEK1), transcription factors (RUNX1, NFYC, NFIB, HIF1A, MEIS2), epigenetic modifiers (DNMT1, DNMT3B, TET3, BRD4, SMARCA4, INO80C) as well as established JAK-signaling targets and mediators of MPN-progression and persistence under JAK inhibitor treatment (YBX1, DUSP6, PIM1, ASXL1, BRD4) [27–31]. This evidence concerns the gene DUSP6 and myeloproliferative disorder.