Of note, among these genes were critical regulators of cell cycle progression (MYC, MYB, MYCBP1, CHEK1), transcription factors (RUNX1, NFYC, NFIB, HIF1A, MEIS2), epigenetic modifiers (DNMT1, DNMT3B, TET3, BRD4, SMARCA4, INO80C) as well as established JAK-signaling targets and mediators of MPN-progression and persistence under JAK inhibitor treatment (YBX1, DUSP6, PIM1, ASXL1, BRD4) [27–31]. The gene discussed is PIM1; the disease is myeloproliferative disorder.