Among the genes with augmented induction in DOT1L-ko cells were members of protein complexes with known tumor suppressor functions (AP1, p53, forkhead transcription factors) as well as apoptosis mediators (CASP1, CASP4, CASP5, CASP10, TLR2, TLR3) (Fig. 4A). This evidence concerns the gene TLR3 and neoplasm.