Clone formation, CCK-8 and transwell experiments showed that compared with CCT196969 alone, combined RXRA knockdown significantly weakened the inhibitory effect on tumor cell proliferation, invasion and migration (Fig. 3M-O), which further confirmed that CCT196969 inhibited TNBC by up-regulating RXRA and down-regulating ASNS. The gene discussed is ASNS; the disease is neoplasm.