For example, when the growth hormone (GH)/Insulin like growth factor (IGF)-1 axis and insulin resistance were measured after intermittent fasting and caloric restriction over two years in non-diabetic obese subjects, metabolic parameters were positively impacted by caloric restriction, while intermittent fasting (with no caloric restriction) enhanced cellular resistance to disease but without weight loss [56]. The gene discussed is GH1; the disease is Insulin resistance.