Moreover, both senescence GBM cells (identified with GFAP, γ-H2AX, and P21 positive, and LaminB1 negative expression) and TAMs (identified with IBA1, γ-H2AX, and P21 positive, and Lamin B1 negative expression) were reduced by GDC-0879 (Fig. 7E). Here, H2AX is linked to glioblastoma.