Consistent with the results obtained from in vitro assays (Fig. S10H, I), IHC staining disclosed a significantly suppressed expression of senescence marker P21 and SASP cytokines like IL6 and IL1β in tumor samples, regardless of GDC-0879 mono- or combined therapy with anti-PD1 (Fig. 7D). The gene discussed is IL1B; the disease is neoplasm.