Moreover, both senescent glioma cells (identified with GFAP, γ-H2AX, and P21 positive, and Lamin B1 negative expression) and TAMs (identified with IBA1, γ-H2AX, and P21 positive, and Lamin B1 negative expression) were reduced by GDC-0879 (Fig. S15E). The gene discussed is AIF1; the disease is central nervous system cancer.