Similar to the observations of GDC-0879 on SASP of GBM cells (Fig. S10J, K), qPCR revealed that GDC-0879 treatment efficiently inhibited the mRNA expression of SASP cytokines (IL1α, IL1β, TNFα, and CXCL10) in senescence-induced THP-1 derived macrophages than Epigallocatechin Gallate, Ruxolitinib, and Rapamycin at their IC50 concentration (Fig. 6A). This evidence concerns the gene IL1A and glioblastoma.