Additionally, RT-qPCR demonstrated that GDC-0879 treatment (10 μM) not only induced a significant reduction in mRNA expression of the SASP-related genes in senescent GBM cells (IL-6, IL1α, IL1β, TNFα, MMP3, CXCL10, and CCL2; Fig. S10H, I), but also exhibited a more efficient inhibition on mRNA expression of SASP cytokines (IL1α, IL1β, TNFα, and CXCL10) than Epigallocatechin Gallate, Ruxolitinib, and Rapamycin at their IC50 concentration (Fig. S10J, K). Here, IL1B is linked to glioblastoma.