PTEN and central nervous system cancer: Through dividing the samples into high and low SASP Score groups using the median SASP Score as a threshold, we observed more EGFR (26.67%), PTEN (27.14%), and NF1 (10%) mutations in the high SASP Score group than low SASP Score group (EGFR (1.90%), PTEN (0.95%), NF1 (4.76%)) of glioma (Fig. 2E).