TNF and glioblastoma: Additionally, RT-qPCR demonstrated that GDC-0879 treatment (10 μM) not only induced a significant reduction in mRNA expression of the SASP-related genes in senescent GBM cells (IL-6, IL1α, IL1β, TNFα, MMP3, CXCL10, and CCL2; Fig. S10H, I), but also exhibited a more efficient inhibition on mRNA expression of SASP cytokines (IL1α, IL1β, TNFα, and CXCL10) than Epigallocatechin Gallate, Ruxolitinib, and Rapamycin at their IC50 concentration (Fig. S10J, K).