ALDH1A3 and intraepithelial neoplasia: Long-term studies revealed that aging KC; Aldh1a3–/– mice (n = 20) for up to one year showed fewer acinar-do-ductal metaplasia (ADM) and intraepithelial neoplasia (PanIN) lesions at 20 and 30 weeks compared to controls, with no invasive PDAC development at one year (0/5), unlike KC mice, where 50% (4/8) developed invasive PDAC (Fig. 3H, I, Fig. S7A, B).