This manuscript shows for the first time to our knowledge the assessment of pediatric/young adults SCD macrophages phenotypes, revealing high expression levels of M1 macrophages phenotypic markers, CCR7 and CD86, together with remarkable lower expression levels of the M2 phenotype marker, CD206, in SCD macrophages compared to the HD ones. This evidence concerns the gene MRC1 and Schnyder corneal dystrophy.