CNR2 and Schnyder corneal dystrophy: Biochemical analysis showed that, in SCD macrophages, CB2 was remarkably higher than HD macrophages (p = 0,0376) with a very large effect size (η2 = 0,7009; 95% CI [0,001742; 0,03564]) (Fig. 3A), thus suggesting that the altered expression of this receptor could be involved in the impaired inflammatory state and in pain development in SCD patients.