TRPV1 and Schnyder corneal dystrophy: Interestingly, considering the role of TRPV1 in SCD pain development, in a pilot safety and feasibility trial (SPICE) it has been tested high-dose (8%) topical capsaicin in pediatric patients with SCD and its-associated neuropathic pain to better clarify the role of capsaicin in pain modulation45.