Moreover, we also observed a concomitant reduction of the M2 phenotype marker CD206 and of pSTAT6, a protein involved in macrophages switching process from pro-inflammatory M1 phenotype to anti-inflammatory M2 one, in SCD macrophages compared to HD ones (p = 0,0231 and p = 0,0154, respectively), with a large effect size (η2 = 0,7626 and η2 = 0,8042, respectively; 95% CI [−1,056; −0,1342] and [−0,2072; −0,03875], respectively) (Fig. 1C, D). Here, MRC1 is linked to Schnyder corneal dystrophy.