We observed significant elevated levels of the pro-inflammatory cytokines IL-6 and TNF-α in SCD macrophages compared to HD macrophages (p = 0,0067 and p = 0,0058, respectively), with a very large effect size (η2 = 0,87 and η2 = 0,88, respectively; 95% CI [498,2; 1662] and [2,33; 7,31], respectively). Here, TNF is linked to Schnyder corneal dystrophy.