To this end, we performed TSPO-PET imaging in 16 patients with subjective cognitive decline (SCD)/ mild cognitive impairment (MCI), 16 AD patients and 14 unaffected controls, staged by Aβ and tau cerebrospinal fluid (CSF) levels, and investigated their TSPO signal in the respective OBs. The gene discussed is MAPT; the disease is Alzheimer disease.