IRS2 and angina pectoris: Specifically, 17 genes (27%) have been associated with myocardial infarction (e.g., HDAC4, HIPK3, and MEIS1), 16 genes (25%) with ischemic heart disease (e.g., GATA5, IRS2, and P2RY13), 15 genes (23%) with stroke (e.g., LEF1, SOX2, and SPARCL1), one with angina (i.e., HDAC4), and 38 genes (59%) with the terms vascular or CVD (e.g., MCF2L and CXXC5).