We used GWAS Catalog to determine whether SNPs annotated to these 64 genes have been associated with CVD or related traits, and we found SNPs annotated to MAP7D3, PPFIA1, NYAP2, and KSR2 associated with CAD and RUFY4 associated with ischemic stroke (Table S2C; Figure 6B). The gene discussed is RUFY4; the disease is ischemic stroke.