IRF4 and aneurysmal bone cyst: Consistent with these alterations, transcriptomic analysis revealed enriched signatures associated with BCL6-, KLF2-, and NOTCH-target genes, ABC-DLBCL, apoptosis, BCR/NF-κB, and T cell exhaustion, along with elevated expression of individual genes including IRF4, NFKBIE, PIM1, BTG2 ETV6, and BLNK (Figures 5B and S2C).