Consistent with these alterations, transcriptomic analysis revealed enriched signatures associated with BCL6-, KLF2-, and NOTCH-target genes, ABC-DLBCL, apoptosis, BCR/NF-κB, and T cell exhaustion, along with elevated expression of individual genes including IRF4, NFKBIE, PIM1, BTG2 ETV6, and BLNK (Figures 5B and S2C). This evidence concerns the gene NFKBIE and aneurysmal bone cyst.