Multiple studies have linked immune cell infiltration to lung cancer survival.29, 30, 31 This study revealed that ZBTB46 expression in LUAD and LUSC is significantly correlated with immune cell infiltration, including B-cells, CD8+ T-cells, CD4+ T-cells, macrophages, neutrophils, Dendritic Cells (DCs), NK cells, pDC, Th1 cells, Tem, TFH, NKT cells, Tem_CD8, and TReg. This evidence concerns the gene CD8A and lung cancer.