ZBTB46 (also known as BTBD4, BZEL, zDC, RINZF, and ZNF340), a BTB-ZF transcription factor and well-established marker of classical Dendritic Cells (cDCs),13,14 has been implicated in gastric,15 neuroendocrine prostate,16 pancreatic,17 and colon cancer.18 Here, ZBTB46 is linked to malignant colon neoplasm.