Patients diagnosed with lung cancer had higher odds of CHIP mutations (OR 1.57, 95% CI 1.40-1.76, P < 0.001, Supplementary Table S3, Figures S4 and S5, available at https://doi.org/10.1016/j.esmoop.2025.105539) and mCAs (OR 1.30, 95% CI 1.20-1.40, P < 0.001, Supplementary Table S4, available at https://doi.org/10.1016/j.esmoop.2025.105539) than patients without lung cancer. The gene discussed is STUB1; the disease is lung carcinoma.