Moreover, those with three or more CHIP mutations had higher risks of incident CVD (HR 1.24, 95% CI 1.04-1.47, P = 0.017), incident CAD (HR 1.36, 95% CI 1.01-1.82, P = 0.041), death from CVD causes (HR 2.28, 95% CI 1.22-4.26, P = 0.010), death from CAD causes (HR 2.40, 95% CI 0.99-5.84, P = 0.053), and death from any cause (HR 1.67, 95% CI 1.33-2.08, P < 0.001). Here, STUB1 is linked to coronary artery disorder.