Risk factors of breast cancer patients for developing brain metastases include young age at diagnosis, multiple extracranial metastatic sites, high tumor grade, large tumor size, nodal involvement, multiple primary sites, and specific molecular subtypes such as human epidermal growth factor receptor 2 – positive (HER-2/neu+) and triple negative breast cancers (TNBC) [5]. The gene discussed is ERBB2; the disease is neoplasm.