In myeloid cells, the BCL‐10/MALT1 complex controls innate immunity and induces inflammatory cytokine production in response to PAMPs and DAMPs, thereby promoting neutrophil activation.[25] Previous studies on the CBM complex have primarily focused on T cells and tumor‐related diseases.[40, 41, 42] In this study, we provide novel insights into the role of the BCL‐10/MALT1 complex in the pathogenesis of sepsis. Here, BCL10 is linked to Sepsis.