HMGB1 and Sepsis: When the infection is not effectively controlled, damage‐associated molecular patterns (DAMPs), such as high‐mobility group box 1 (HMGB1), are released, further amplifying the inflammatory response and contributing to immune dysregulation.[7] Clinical studies indicate that ≈25% to 50% of sepsis patients develop disseminated intravascular coagulation (DIC), a pathological condition closely associated with poor prognosis.[8] In the later stages of sepsis, the excessive immune response not only triggers a cytokine storm but also activates the coagulation pathway.