One of the main recognisable pathological effects of AD is the presence of amyloid-beta (A\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}) plaques and neurofibrillary tangles composed of tau protein in the brain of AD patients. This evidence concerns the gene MAPT and Alzheimer disease.