While miR-30a-5p and miR-34a-5p have been shown to decrease COMT expression, another miRNA, miR-148b-3p, is noted for its role in regulating COMT indirectly by targeting the ZNF804A gene, which in turn affects COMT expression in human neuroblastoma cells (Wu et al. 2020). Here, COMT is linked to neuroblastoma.