ALK and neuroblastoma: A functional screen in which > 1,200 miRNAs were transfected into NB cells identified miR-99b-5p, miR-380-3p and miR-485-3p as promoting chemosensitivity [104], whilst a CRISPR-Cas9 knockout screen identified miR-1304-5p as a desensitizing agent to ALK-directed tyrosine kinase inhibitors [115].