Its promotion of NB is likely attributed to the modulation of multiple signalling pathways including AKT (described above), the Wnt pathway through direct repression of the Wnt modulator DKK3 [73, 74], and the suppression of TGF-β signalling via multiple miR-17-92 family members targeting multiple TGF-β pathway components [75]. Here, TGFB1 is linked to neuroblastoma.