Indeed, hnRNP K cytoplasmic mislocalization has been reported in FTLD, Alzheimer’s disease, and C9orf72-related ALS (Braems et al., 2022; Sidhu et al., 2022), suggesting a link to TDP-43 functional impairment in these neurodegenerative diseases. The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.