A recent study suggested the importance of splicing regulation by multiple RBPs in neuronal homeostasis, demonstrating that an ALS-associated synaptic ras GTPase activating protein 1 (SYNGAP1) 3′ UTR variant recruits excessive FUS and hnRNP K, with hnRNP K driving aberrant splicing that SYNGAP1 isoform α1 over γ, leading to dendritic spine loss (Yokoi et al., 2022). This evidence concerns the gene SYNGAP1 and amyotrophic lateral sclerosis.