TARDBP and amyotrophic lateral sclerosis: Cytoplasmic mislocalization and nuclear depletion of hnRNP K, as well as the loss of hnRNP A1, were observed in postmortem neural tissues of ALS and FTLD patients (Bampton et al., 2021; Braems et al., 2022; Honda et al., 2015; Sidhu et al., 2022), indicating that these RBP abnormalities may contribute to TDP-43 dysregulation.