This review will not be exhaustive of all publications related to CF from the past year but will focus on clinical topics related to newborn screening (NBS), CF transmembrane conductance regulator (CFTR)‐Related Metabolic Syndrome/Cystic Fibrosis Screen Positive Inconclusive Diagnosis (CRMS/CFSPID), pulmonary exacerbations, use of acid suppression, CFTR modulators, and new/updated guidelines. This evidence concerns the gene CFTR and metabolic syndrome.