CFTR and cystic fibrosis: CRMS/CFSPID is defined as people with an abnormal CF NBS result and (1) a sweat chloride of < 30 mmol/L and 2 CFTR variants, at least one of which has unclear phenotypic consequences or (2) a sweat chloride of ≥ 30 to 59 mmol/L and one or no CF‐causing variants [7].