A study by Rebecca Lee et al. [87] demonstrated that monocytes from SSc patients lacked Cav‐1, which disrupts the regulation of chemokine receptors (CCR1, CCR2, and CCR3) through mitogen‐activated extracellular signal‐regulated kinase (MEK)/ERK and Src/Lyn signaling pathways. This evidence concerns the gene MAP2K7 and systemic sclerosis.