METTL3 and infection: For example, the nuclear-cytoplasmic transport of m6A modification enzymes (e.g., METTL3/METTL14) during early infection is mediated by ICP27, but the specific molecular mechanisms (such as whether phosphorylation or acetylation modifications are involved) remain unclear [62]; Addtionally, while HSV-1 infection causes YTHDF proteins to degrade host m6A-modified transcripts, it remains unknown whether the virus's own mRNA evade recognition through a similar mechanism.