METTL3 and infection: Recent advancements in m6A modification sequencing methods have led to the identification of at least 12 m6A modification peaks within HSV-1 transcripts, encompassing genes such as UL1, UL2, UL12, UL28, UL29, UL38, UL39, UL42, UL46, UL49, US10, US11, and US12. Following HSV-1 infection, an increase in the expression levels of the RNA methyltransferases METTL3 and METTL14, along with the YTHDF family of m6A readers (YTHDF1, YTHDF2, and YTHDF3), has been observed at the early stages of infection.