Mechanistically, circNHSL1 sponges miR-1306-3p to reduce its inhibitory effect on SIX1 (a transcription factor), so SIX1 intensifies the expression of Vimentin, a mesenchymal marker, to promote EMT, thus inducing motility, metastasis, and invasion in GC cells. The gene discussed is SIX1; the disease is gastric cancer.