In addition, preparation for RAI therapy requires discontinuation of thyroid hormone or recombinant TSH and a low iodine diet, which reduces quality of life, and the risk of complications associated with repeated iodine-131 treatments with high iodine uptake, such as xerostomia, recurrent sialoadenitis and pulmonary fibrosis, also need to be taken into account (33, 34). This evidence concerns the gene TG and pulmonary fibrosis.