In the univariate and multivariate GLM (Model 1) adjusted by age, male, DM, and depression were all associated with higher prevalence of POAG and AD (all p<0.05), while carrying APOE E4 is a protective factor for prevalence of POAG with borderline significance (univariable GLM: OR=0.898, p=0.046; multivariate GLM: OR=0.899, p=0.047) but significant risk factor for prevalence of AD (univariate GLM: OR=4.279, p<0.001; multivariate GLM: OR=4.271, p<0.001). This evidence concerns the gene APOE and open-angle glaucoma.