In the univariable GLM adjusted by age, factors like POAG, DM, female, and worse VA were all associated with higher prevalence of depression (ORPOAG=1.580, p<0.001; ORDM=1.952, p<0.001; ORGender=0.697, p<0.001; βVA=1.087 ± 0.086, p<0.001), while carrying APOE E4 was not associated with depression(p=0.100). The gene discussed is APOE; the disease is depressive disorder.