Lowe syndrome was discovered in the 1950’s (Lowe et al., 1952), but it was not until the early 1990’s that the causative gene was identified as OCRL (Attree et al., 1992), which encodes an inositol 5-phosphatase that has been extensively studied since, and which I describe further below. This evidence concerns the gene OCRL and oculocerebrorenal syndrome.