However, genetic background is also a likely factor considering that in some cases the same mutation in OCRL can result in either Dent-2 disease or Lowe syndrome, and Lowe syndrome of varying severity can also result from the same mutation in OCRL (Hichri et al., 2011; Montjean et al., 2015; Gianesello et al., 2021). Here, OCRL is linked to Dent disease.