OCRL and Dent disease: Over recent years our understanding of OCRL cellular function has improved markedly, and animal models have been developed to investigate the mechanisms underlying Lowe syndrome and Dent-2 disease (Loovers et al., 2007; Bothwell et al., 2011; Ramirez et al., 2012; Cheng et al., 2015; Del Signore et al., 2017).