Rescue experiments also showed that reducing the excess PI(4,5)P2 seen in OCRL-deficient zebrafish larvae by knocking down PIP5-kinase could restore renal tubular endocytosis (Oltrabella et al., 2015), consistent with this representing a valid therapeutic target for Lowe syndrome and Dent-2 disease. This evidence concerns the gene OCRL and oculocerebrorenal syndrome.