Toward this end, we investigated MGST1 function in LSCC cells and observed that silencing MGST1 significantly inhibited tumor cell proliferation, migration, and invasion (Figures 5D,F), likely through downstream suppression of PIK3CA, NF-KB, β-catenin and GSK3β (Figure 7C). This evidence concerns the gene NFKB1 and neoplasm.