Among these, the LRP1B and USH2A, which are common mutant genes across various cancer types (Brown et al., 2021; López et al., 2023; Möhrmann et al., 2022; Yang et al., 2023), were found to be highly expressed in the lymphatic metastasis group (Supplementary Figure 1C) (Han et al., 2021). The gene discussed is LRP1B; the disease is cancer.