The elevation of MGST1 has demonstrated enhanced cell proliferation, migration, invasion of trophoblast by the activation of the PI3K/AKT/mTOR pathway (Dai and Lu, 2022), and activation of the AKT/GSK-3β/β-catenin axis in gastric cancer cells (Li et al., 2023c). This evidence concerns the gene PIK3CA and gastric cancer.