BLACAT1 inhibits the trimethylation of H3K27 on the CDKN1C gene by blocking the recruitment of EZH2, thereby promoting the expression of CDKN1C and inhibiting the expression of CCNE, and thus suppressing the biological processes of pancreatic cancer cells (Zhou et al., 2020). Here, CDKN1C is linked to familial pancreatic carcinoma.