IL1R1 and neoplasm: We used different knockout mice (TLR2–/–, TLR3–/–, TLR4–/–, TLR7–/–, TLR9–/–, MyD88–/–, STING–/–, cGAS–/–, IFNAR–/–, IL-1R–/–, caspase 1/11–/–, and gasdermin D–/–); we found that only MyD88 was essential for tumor regression and important for the induction of cellular infiltrate and inflammatory profile modulation in the TME in response to BCG intratumoral treatment.