The PI3K-AKT pathway is commonly activated in malignant cells and is associated with processes such as cell proliferation, metastasis, and chemotherapeutic resistance across a spectrum of malignancies, including endometrial (Wik et al., 2013), gastric (Huang et al., 2017), breast (Luo et al., 2018), and lung (Jin et al., 2022) cancers. The gene discussed is AKT1; the disease is cancer.