In contrast to rs2279744 of the MDM2 gene, where a statistically significant association between the above SNP and the development of bladder cancer was found in the Southeastern European and Western Asian regions (Turkey) under the genetic models: G vs. T (P-value= 0.015; OR 95%CI= 1.51 [1.084; 2.125]), GG vs. TT (P-value= 0.009; OR 95% CI= 2.60 [1.262; 5.370]). Here, MDM2 is linked to urinary bladder carcinoma.