The sensitivity analysis revealed that the Arg72Pro of the TP53 gene and the T309G of the MDM2 gene had a deleterious effect on bladder cancer (Fig 3) for the rs1042522 of the TP53 gene, its association is in agreement with the meta-analyses conducted on Asian populations that were performed by Liu et al30, Yang et al (31), and Zhang et al (32), and in discordance with the work of33 performed on Caucasian, where no association was found. This evidence concerns the gene MDM2 and urinary bladder cancer.