The genotyping technique PCR-RFLP was found to be associated with the diagnosis of bladder cancer when it was applied to rs1042522 of the TP53 gene: Recessive model CC vs. CG+GG: (P value= 0.025; OR 95% CI= 1.37 [1.038; 1.815]); CC vs.GG (P value= 0.003; OR 95% CI= 1.588 [1.163; 2.167]). This evidence concerns the gene TP53 and urinary bladder carcinoma.