AKT1 and gastric cancer: At the same time, the scratch healing rate in the si-2 group was also lower than that in the si-NC group and si-1 group, i.e., Knockdown of Sema6D could down-regulate p-PI3K, ERK/p-ERK, AKT/p-AKT, mTOR/p-mTOR, and other protein expression levels in gastric cancer tissues, thereby inhibiting cancer cell migration and invasion.