IGFBP3 and chronic myelogenous leukemia, BCR-ABL1 positive: We found that IGFBP-1, IGFBP-3 genes expression and IGFBP-1, IGFBP-3 levels were significantly higher in CML patients compared to controls (p< 0.001 for each) while IGFBP-2 gene expression and IGFBP-2 level did not differ significantly between both groups (p= 0.264 and 0.149, respectively).