IGFBP1 and chronic myelogenous leukemia, BCR-ABL1 positive: IGFBP 1, IGFBP 3 genes expression and IGFBP 1, IGFBP 3 levels were significantly higher in CML patients compared to controls (p< 0.001 for each), while IGFBP 2 gene expression and IGFBP 2 level did not differ significantly between both groups (p= 0.264 and 0.149, respectively) that described in Table (3) and Fig. (2,3).