8-iso-prostaglandin F2α (8-iso-PGF2α) and pulmonary surfactant associated protein D (SP-D) are newly discovered cytokines in recent years, and studies4,5 have confirmed that 8-iso-PGF2α and SP-D are closely related to the occurrence and development of severe pneumonia . Here, SFTPD is linked to susceptibility to pneumonia measurement.