For example, ANXA2 knockdown leads to an increase in radiation-induced apoptosis in radioresistant nasopharyngeal carcinoma (NPC) cells, whereas an elevation in ANXA2 expression leads to a decrease in radiation-induced apoptosis in NPC cells (48); the 2A protein from the encephalomyocarditis virus inhibits the JNK/c-Jun signaling pathway through its interaction with ANXA2, facilitating apoptosis in BHK21 cells during the early phases of virus replication (49). The gene discussed is MAPK8; the disease is nasopharyngeal carcinoma.