The expression of SIRT1, SIRT3, and SIRT6 in the saliva of AD was identified to be 1.5–4.9-fold reduced compared to the health senile group SIRT6 was 2.5–4.5-fold lower than in healthy (Pukhalskaia et al. 2020).Experiments on animal models has proved intermittent food deprivation decreases hyperexcitability of neuronal network and augments deficits in hippocampal synaptic plasticity in a SIRT3-dependent manner (Ruankham et al. 2021). Here, SIRT1 is linked to Alzheimer disease.