MAPT and Alzheimer disease: Dysregulation of the metabolic pathway, coupled with loss of mitochondrial function activate AMPK signalling, contributing to the core hallmarks of AD, including Aβ accumulation, tau aggregation, and oxidative stress (Herzig and Shaw 2018), ultimately leading to neurofibrillary tangle formation and Aβ plaque deposition (Caberlotto et al. 2013).