Notably, cancer biology reveals conserved lncRNA-mediated necroptosis regulation relevant to neurological contexts: Colon cancer studies identify a 6-lncRNA signature modulating TNF-α/NF-κB-driven necroptosis (Liu et al., 2022), gastric adenocarcinoma research shows 12 lncRNAs regulating caspase-8/FADD-mediated death (Luo et al., 2022), and lung adenocarcinoma models reveal 7 prognostic lncRNAs linked to MLKL ubiquitination (Lu et al., 2022). This evidence concerns the gene CASP8 and cancer.