SNHG1 and Parkinson disease: In microglia, Parkinson’s-associated SNHG1 amplifies pyroptosis via the miR-7/NLRP3 axis (Cao et al., 2018; Zhou et al., 2016), spinal injury-induced F630028O10Rik hijacks TLR4/PI3K/AKT signaling to trigger inflammasome activation (Xu et al., 2020), and diabetic hyperglycemia elevates Fendrr expression to stabilize NLRC4 through HERC2-mediated anti-ubiquitination (Wang L. Q. et al., 2021).