MTOR and brain ischemia: In cerebral ischemia, C2dat2 sequesters miR-30d-5p to activate DDIT4-dependent autophagy and apoptosis, potentiating reperfusion injury (Xu et al., 2021), while SNHG12 silencing amplifies mesenchymal stem cell efficacy by activating PI3K/AKT/mTOR signaling (Li et al., 2019).