SMARCB1 and neoplasm: It is believed that RMC is triggered by chronic hypoxia due to inadequate blood supply caused by sickle cells (5), additionally, there is an important association with the SMARCB1 gene (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily B, member 1), which acts as a tumor suppressor on chromosome 22 at position 11.23 (22q11.23) (19, 20), considering its loss in the SWI/SNF complex, which mediates chromatin remodeling and modulates transcriptional activity in various neoplasms, it suggests its suppressor function (5).