Iterative clustering of the tumor-derived cells identified 40 distinct clusters based on chromatin accessibility profiles, including 13 malignant clusters (EPCAM, KRT18), 2 stromal clusters (VWF, PECAM1, COL1A2, FBLN1), 10 T cell clusters (CD3D, CD8A, CD4), 3 NK/ILC clusters (NCR1), 10 myeloid clusters (CD14, LYZ, HLA-DQA1, KIT), 1 B cell cluster (MS4A1, PAX5), and 1 plasma cell cluster (TNFRSF17, Figure S3C). The gene discussed is CD8A; the disease is neoplasm.