In addition, studies have shown that soy isoflavones are phytoestrogens with physiological functions such as preventing osteoporosis, increasing bone density and bone strength in rats with osteoporotic fractures, promoting the expression of vascular endothelial growth factor and osteoprotegerin at the fracture end, improving the histological environment, and promoting the healing of osteoporotic fractures (32, 33). This evidence concerns the gene TNFRSF11B and osteoporosis.