According to the National Comprehensive Cancer Network (NCCN) (https://www.nccn.org/guidelines/category_2), different genetic variants are associated with varying risks of epithelial ovarian cancer (EOC), with BRCA1 variants conferring an absolute risk of 39–58%, BRCA2 variants 13–29%, and BRIP1 variants 5–15%. The gene discussed is BRCA1; the disease is ovarian carcinoma.