Our pan-cancer analysis of TCGA data revealed consistent and significant SMYD2 upregulation across multiple malignancies including GC, breast cancer, colorectal adenocarcinoma, renal cell carcinoma, and prostate cancer (Figures 3B, C), validating and extending prior reports (16, 43–45). This evidence concerns the gene SMYD2 and hereditary clear cell renal cell carcinoma.