Even though this SNP genotype (C>T) does not affect the sequence of any nearby gene, they reported that patients with the homozygous genotype for the minor allele (T/T) were 88% more likely to have HER2-positive breast tumors (OR=1.88; 95% CI, 1.33-2.65, p=0.00033), compared to patients with the C/C genotype. This evidence concerns the gene ERBB2 and breast neoplasm.