These findings consistently demonstrate a clear association between HER2-positive tumors and AA, Asian, and Latina ethnicities, suggesting the presence of disparities in the distribution of breast cancer subtypes among minority groups in the U.S. However, it is important to note that breast tumor subtype classification is often conducted based on the IHC expression of ER, PR and HER2 biomarkers (42). Here, ERBB2 is linked to breast neoplasm.